Giulia Monacelli, University of Pisa /UBT- Umbria Bioengineering Technologies, Italy; Eliana Canicatti', University of Pisa/RaSS National Laboratory CNIT, Italy; Alessandro Vispa, Lorenzo Sani, UBT- Umbria Bioengineering Technologies, Italy; Gianluigi Tiberi, London South Bank University/ UBT- Umbria Bioengineering Technologies, Italy; Agostino Monorchio, University of Pisa/RaSS National Laboratory, CNIT, Italy